ITM3786
ITM3786
- Catalog: ITM3786
- Gene/Protein: NBR1 1A13B KIAA0049 M17S2 MIG19
- Product Description: Immunotag™ NBR1 Rabbit Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | NBR1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p |
| Recommended Dilution | IHC-p 1:50-300 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Recombinant Protein of NBR1 |
| Specificity | The antibody detects endogenous NBR1 protein |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | NBR1 1A13B KIAA0049 M17S2 MIG19 |
| Accession No. | Q14596 P97432 Q501R9 |
| Alternate Names | Next to BRCA1 gene 1 protein (Cell migration-inducing gene 19 protein) (Membrane component chromosome 17 surface marker 2) (Neighbor of BRCA1 gene 1 protein) (Protein 1A1-3B) |
| Description | NBR1, autophagy cargo receptor(NBR1) Homo sapiens The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014], |
| Protein Expression | Bone marrow,Lymph,Ovary,Testis, |
| Subcellular Localization | pre-autophagosomal structure,mitochondrion,lysosome,late endosome,autophagosome,cytosol,membrane,cytoplasmic vesicle,M band,extracellular exosome, |
| Protein Function | caution:Was originally (PubMed:8069304) thought to be the ovarian carcinoma antigen CA125.,domain:The OPR domain mediates interaction with SQSTM1.,similarity:Contains 1 OPR domain.,similarity:Contains 1 UBA domain.,similarity:Contains 1 ZZ-type zinc finger.,subunit:Homooligomer and heterooligomer. Interacts with SQSTM1, titin/TTN and RNF29., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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