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ITN0063

ITN0063
  • Gene/Protein: PNKP
  • Product Description: Immunotag™ PNKP Polyclonal Antibody
280.0000
Price in reward points: 294

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Immunotag™ PNKP Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein PNKP
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000
Concentration 1 mg/ml
Reactive Species Human
Host Species Rabbit
Immunogen Synthesized peptide derived from human protein . at AA range: 50-130
Specificity PNKP Polyclonal Antibody detects endogenous levels of protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Gene Name PNKP
Accession No. Q96T60 Q9JLV6
Description polynucleotide kinase 3'-phosphatase(PNKP) Homo sapiens This locus represents a gene involved in DNA repair. In response to ionizing radiation or oxidative damage, the protein encoded by this locus catalyzes 5' phosphorylation and 3' dephosphorylation of nucleic acids. Mutations at this locus have been associated with microcephaly, seizures, and developmental delay.[provided by RefSeq, Sep 2010],
Protein Expression Blood,Epithelium,Ovary,
Subcellular Localization nucleus,nucleoplasm,nucleolus,mitochondrion,membrane,
Protein Function catalytic activity:A 3'-phosphopolynucleotide + H(2)O = a polynucleotide + phosphate.,catalytic activity:ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA.,function:Catalyzes the phosphorylation of DNA at 5'-hydroxyl termini and can dephosphorylate its 3'-phosphate termini. Plays an important function in DNA repair following ionizing radiation or oxidative damage.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:In the N-terminal section; belongs to the DNA 3' phosphatase family.,tissue specificity:Expressed in many tissues with highest expression in spleen and testis, and lowest expression in small intestine (PubMed:10446192). Expressed in higher amount in pancreas, heart and kidney and at lower levels in brain, lung and liver (PubMed:10446193).,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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