ITN0063
ITN0063
- Catalog: ITN0063
- Gene/Protein: PNKP
- Product Description: Immunotag™ PNKP Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | PNKP |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 50-130 |
| Specificity | PNKP Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | PNKP |
| Accession No. | Q96T60 Q9JLV6 |
| Description | polynucleotide kinase 3'-phosphatase(PNKP) Homo sapiens This locus represents a gene involved in DNA repair. In response to ionizing radiation or oxidative damage, the protein encoded by this locus catalyzes 5' phosphorylation and 3' dephosphorylation of nucleic acids. Mutations at this locus have been associated with microcephaly, seizures, and developmental delay.[provided by RefSeq, Sep 2010], |
| Protein Expression | Blood,Epithelium,Ovary, |
| Subcellular Localization | nucleus,nucleoplasm,nucleolus,mitochondrion,membrane, |
| Protein Function | catalytic activity:A 3'-phosphopolynucleotide + H(2)O = a polynucleotide + phosphate.,catalytic activity:ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA.,function:Catalyzes the phosphorylation of DNA at 5'-hydroxyl termini and can dephosphorylate its 3'-phosphate termini. Plays an important function in DNA repair following ionizing radiation or oxidative damage.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:In the N-terminal section; belongs to the DNA 3' phosphatase family.,tissue specificity:Expressed in many tissues with highest expression in spleen and testis, and lowest expression in small intestine (PubMed:10446192). Expressed in higher amount in pancreas, heart and kidney and at lower levels in brain, lung and liver (PubMed:10446193)., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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