ITN0157
ITN0157
- Catalog: ITN0157
- Gene/Protein: WBP7 HRX2 KIAA0304 KMT2B MLL2 MLL4 TRX2
- Product Description: Immunotag™ MLL4 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | MLL4 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p |
| Recommended Dilution | IHC-p 1:50-300 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 1060-1140 |
| Specificity | MLL4 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | WBP7 HRX2 KIAA0304 KMT2B MLL2 MLL4 TRX2 |
| Accession No. | Q9UMN6 O08550 |
| Description | lysine methyltransferase 2B(KMT2B) Homo sapiens This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. This gene is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene, however, the full length nature of the shorter transcript is not known. [provided by RefSeq, Jul 2008], |
| Protein Expression | Bone marrow,Brain,Epithelium,Leukocyte,Placenta,Skin,Testis, |
| Subcellular Localization | nucleus,nucleoplasm,histone methyltransferase complex, |
| Protein Function | catalytic activity:S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.,caution:This protein was first named MLL2 by PubMed:10637508 and PubMed:10409430. MLL2 corresponds to another protein located on chromosome 12 (see AC O14686).,disease:Often amplified in pancreatic carcinomas.,function:Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamily.,similarity:Contains 1 CXXC-type zinc finger.,similarity:Contains 1 post-SET domain.,similarity:Contains 1 SET domain.,similarity:Contains 3 A.T hook DNA-binding domains.,similarity:Contains 3 PHD-type zinc fingers.,subunit:Component of the MLL3/MLL4 complex, at least composed of MLL3, MLL4, ASH2L, RBBP5, DPY30, WDR5, NCOA6, KDM6A (or KDM6B), PAXIP1/PTIP and C16orf53/PA1.,tissue specificity:Widely expressed. Highest levels in testis. Also found in brain, bone marrow, heart, muscle, kidney, pancreas, spleen, thymus, prostate, ovary, intestine, colon, peripheral blood lymphocytes, and placenta., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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