ITN0235
ITN0235
- Catalog: ITN0235
- Gene/Protein: ITGA11 MSTP018
- Product Description: Immunotag™ ITA11 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | ITA11 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 30-110 |
| Specificity | ITA11 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | ITGA11 MSTP018 |
| Accession No. | Q9UKX5 P61622 |
| Description | integrin subunit alpha 11(ITGA11) Homo sapiens This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Focal adhesion,ECM-receptor interaction,Regulates Actin and Cytoskeleton,Hypertrophic cardiomyopathy (HCM),Arrhythmogenic right ventricular cardiomyopathy (ARVC),Dilated cardiomyopathy, |
| Protein Expression | Aorta,Fetal heart,Fetal muscle,Fibroblast,Liver,Osteoblast,Uterus, |
| Subcellular Localization | plasma membrane,focal adhesion,integrin complex,membrane,integrin alpha11-beta1 complex, |
| Protein Function | developmental stage:Strongly up-regulated in differentiating fetal muscle cells (in vitro).,domain:The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.,function:Integrin alpha-11/beta-1 is a receptor for collagen.,similarity:Belongs to the integrin alpha chain family.,similarity:Contains 1 VWFA domain.,similarity:Contains 7 FG-GAP repeats.,subunit:Heterodimer of an alpha and a beta subunit. Alpha-11 associates with beta-1. Interacts with RAB21.,tissue specificity:According PubMed:10464311 highest levels in uterus and heart, intermediate levels in skeletal muscle and intermediate to low levels in pancreas, kidney and placenta. According to PubMed:10486209 also found in brain, colon, lung, small intestine, stomach, testis, salivary glands, thyroid glands and prostate. Very low levels in peripheral blood lymphocytes, fetal brain and fetal liver., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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