ITN0304
ITN0304
- Catalog: ITN0304
- Gene/Protein: CDC45 CDC45L CDC45L2 UNQ374/PRO710
- Product Description: Immunotag™ CDC45 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | CDC45 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 90-170 |
| Specificity | CDC45 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | CDC45 CDC45L CDC45L2 UNQ374/PRO710 |
| Accession No. | O75419 Q9Z1X9 |
| Description | cell division cycle 45(CDC45) Homo sapiens The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013], |
| Cell Pathway/ Category | Cell_Cycle_G1S,Cell_Cycle_G2M_DNA, |
| Protein Expression | Brain,Lung,Muscle, |
| Subcellular Localization | nucleus,nucleoplasm,nuclear pre-replicative complex,cytoplasm,centrosome,DNA replication preinitiation complex,replication fork protection complex, |
| Protein Function | developmental stage:Transcript peaks at G1-S transition, but total protein remains constant throughout the cell cycle. Expressed in multiple tissues during embryogenesis, including neural crest-derived structures.,function:Required for initiation of chromosomal DNA replication.,similarity:Belongs to the CDC45 family.,subunit:Associated with ORC2L.,tissue specificity:Widely expressed, highest levels are found in adult testis and tyhmus and in fetal liver., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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