ITN0335
ITN0335
- Catalog: ITN0335
- Gene/Protein: ORC2 ORC2L
- Product Description: Immunotag™ ORC2 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | ORC2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein, at AA range: 180-260 |
| Specificity | ORC2 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | ORC2 ORC2L |
| Accession No. | Q13416 Q60862 Q75PQ8 |
| Description | origin recognition complex subunit 2(ORC2) Homo sapiens The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3, -4, and -5. It also interacts with CDC45 and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication. Alternatively spliced transcript variants have been found, one of which is a nonsense-me |
| Cell Pathway/ Category | Cell_Cycle_G1S,Cell_Cycle_G2M_DNA, |
| Protein Expression | Placenta, |
| Subcellular Localization | nuclear chromosome, telomeric region,heterochromatin,origin recognition complex,condensed chromosome inner kinetochore,nucleus,nucleoplasm,nuclear origin of replication recognition complex,centrosome,membrane, |
| Protein Function | function:Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication in an ATP-dependent manner.,similarity:Belongs to the ORC2 family.,subunit:ORC is composed of six subunits. Interacts with DBF4 (By similarity). Interacts with MCM10., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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