ITN0386
ITN0386
- Catalog: ITN0386
- Gene/Protein: INPP5E
- Product Description: Immunotag™ INP5E Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | INP5E |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein, at AA range: 490-570 |
| Specificity | INP5E Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | INPP5E |
| Accession No. | Q9NRR6 Q9JII1 Q9WVR1 |
| Description | inositol polyphosphate-5-phosphatase E(INPP5E) Homo sapiens The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016], |
| Cell Pathway/ Category | Inositol phosphate metabolism,Phosphatidylinositol signaling system, |
| Protein Expression | Brain,Fetal brain, |
| Subcellular Localization | ruffle,cytosol,plasma membrane,axoneme,Golgi cisterna membrane,primary cilium, |
| Protein Function | catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.,function:Converts phosphatidylinositol-3,4,5-triphosphate (PtdIns 3,4,5-P3) to PtdIns-P2. Specific for lipid substrates, inactive towards water soluble inositol phosphates.,miscellaneous:Active in the presence of octyl-glucoside or Triton X-100, but completely inhibited by CTAB.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Several sequencing problems.,similarity:Belongs to the inositol-1,4,5-trisphosphate 5-phosphatase type IV family.,subcellular location:Peripheral membrane protein associated with Golgi stacks.,tissue specificity:Detected in brain, heart, pancreas, testis and spleen., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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