ITN0442
ITN0442
- Catalog: ITN0442
- Gene/Protein: PDS5B APRIN AS3 KIAA0979
- Product Description: Immunotag™ PDS5B Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | PDS5B |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein, at AA range: 90-170 |
| Specificity | PDS5B Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | PDS5B APRIN AS3 KIAA0979 |
| Accession No. | Q9NTI5 Q4VA53 Q6TRW4 |
| Description | PDS5 cohesin associated factor B(PDS5B) Homo sapiens This gene encodes a protein that interacts with the conserved protein complex termed cohesin. The cohesin complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene. [provided by RefSeq, Jul 2015], |
| Protein Expression | Brain,Colon,Prostate,T-cell,Testis, |
| Subcellular Localization | chromosome, centromeric region,chromatin,nucleus,nucleoplasm,chromosome,cytosol, |
| Protein Function | disease:Defects in PDS5B may be the cause of some cancers including esophageal cancer.,function:Plays a role in androgen-induced proliferative arrest in prostate cells. Required for maintenance of sister chromatid cohesion during mitosis.,induction:By the synthetic androgen R1881 in prostate carcinoma cells undergoing proliferative arrest. Maximum levels occur 18-20 hours after androgen exposure.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the PDS5 family.,similarity:Contains 1 HEAT repeat.,similarity:Contains 3 A.T hook DNA-binding domains.,subunit:Interacts with the cohesin complex.,tissue specificity:Widely expressed., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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