ITN0569
ITN0569
- Catalog: ITN0569
- Gene/Protein: M6PR MPR46 MPRD
- Product Description: Immunotag™ MPRD Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | MPRD |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | MPRD Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | M6PR MPR46 MPRD |
| Accession No. | P20645 P24668 Q6AY20 |
| Description | mannose-6-phosphate receptor, cation dependent(M6PR) Homo sapiens This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, May 2011], |
| Cell Pathway/ Category | Lysosome, |
| Protein Expression | Leukocyte,Liver,Muscle,Uterus, |
| Subcellular Localization | lytic vacuole,lysosomal membrane,endosome,late endosome,trans-Golgi network,integral component of plasma membrane,membrane,integral component of membrane,transport vesicle,retromer complex,trans-Golgi network membra |
| Protein Function | domain:The extracellular domain is homologous to the repeating units (of approximately 147 AA) of the cation-independent mannose 6-phosphate receptor.,function:Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.,miscellaneous:This receptor has optimal binding in the presence of divalent cations.,subunit:Homodimer. Binds GGA1, GGA2 and GGA3., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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