ITN0636
ITN0636
- Catalog: ITN0636
- Gene/Protein: DOCK7 KIAA1771
- Product Description: Immunotag™ DOCK7 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | DOCK7 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | DOCK7 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | DOCK7 KIAA1771 |
| Accession No. | Q96N67 Q8R1A4 |
| Description | dedicator of cytokinesis 7(DOCK7) Homo sapiens The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that plays a role in axon formation and neuronal polarization. The encoded protein displays GEF activity toward RAC1 and RAC3 Rho small GTPases but not toward CDC42. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012], |
| Protein Expression | Brain,Epithelium,Fetal brain,Mesangial cell,Ovary,Thalamus,Thymus, |
| Subcellular Localization | intracellular,focal adhesion,COP9 signalosome,integral component of membrane,axon,growth cone,neuron projection,basal part of cell, |
| Protein Function | domain:The DHR-2 domain mediates GEF activity.,function:Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization.,similarity:Belongs to the DOCK family.,similarity:Contains 1 DHR-1 (CZH-1) domain.,similarity:Contains 1 DHR-2 (CZH-2) domain.,subcellular location:Enriched in the developing axons of hippocampal neurons.,subunit:Interacts with TSC1. Interacts with nucleotide-free RAC1 and RAC3.,tissue specificity:Widely expressed., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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