ITN0641
ITN0641
- Catalog: ITN0641
- Gene/Protein: DSG4 CDHF13
- Product Description: Immunotag™ DSG4 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | DSG4 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | DSG4 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | DSG4 CDHF13 |
| Accession No. | Q86SJ6 Q7TMD7 Q6W3B0 |
| Description | desmoglein 4(DSG4) Homo sapiens This gene encodes a member of the desmoglein subgroup of desmosomal cadherins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a transmembrane component of desmosomes and may play a role in cell-cell adhesion in epithelial cells. Mutations in the gene are associated with localized autosomal recessive hypotrichosis and monilethrix, characterized by impaired hair growth. [provided by RefSeq, May 2016], |
| Protein Expression | Epidermis,Epithelium,Skin,Testis, |
| Subcellular Localization | plasma membrane,integral component of membrane,desmosome, |
| Protein Function | disease:Defects in DSG4 are the cause of localized autosomal hypotrichosis (LAH) [MIM:607903]. LAH is an autosomal recessive skin disorder. Affected members displayed hypotrichosis restricted to the scalp, chest, arms and legs. It is characterized by abnormal hair follicles and shafts, which are thin and atrophic.,disease:DSG4 is one of the target molecules recognized by autoantibodies in patients with pemphigus vulgaris. Pemphigus vulgaris is a potentially lethal skin disease in which epidermal blisters occur as the result of the loss of cell-cell adhesion.,domain:Calcium may be bound by the cadherin-like repeats .,function:Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes.,similarity:Contains 4 cadherin domains.,tissue specificity:Highly expressed in skin, testis and prostate; less in salivary gland. In scalp follicles, present in the inner rooth sheath (IRS) and all layers of the matrix and precortex., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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