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ITN0655

ITN0655
  • Gene/Protein: POLR1A
  • Product Description: Immunotag™ RPA1 Polyclonal Antibody
280.0000
Price in reward points: 294

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Immunotag™ RPA1 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein RPA1
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000
Concentration 1 mg/ml
Reactive Species Human
Host Species Rabbit
Immunogen Synthesized peptide derived from part region of human protein
Specificity RPA1 Polyclonal Antibody detects endogenous levels of protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Gene Name POLR1A
Accession No. O95602 O35134 O54889
Description RNA polymerase I subunit A(POLR1A) Homo sapiens The protein encoded by this gene is the largest subunit of the RNA polymerase I complex. The encoded protein represents the catalytic subunit of the complex, which transcribes DNA into ribosomal RNA precursors. Defects in this gene are a cause of the Cincinnati type of acrofacial dysostosis. [provided by RefSeq, May 2016],
Cell Pathway/ Category Purine metabolism,Pyrimidine metabolism,RNA polymerase,
Protein Expression Colon,Skin,Uterus,
Subcellular Localization nucleus,nucleoplasm,nucleolus,DNA-directed RNA polymerase I complex,cytoplasm,
Protein Function catalytic activity:Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).,function:DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.,PTM:Phosphorylated.,similarity:Belongs to the RNA polymerase beta' chain family.,subunit:Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits. Interacts with MYO1C.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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