ITN0655
ITN0655
- Catalog: ITN0655
- Gene/Protein: POLR1A
- Product Description: Immunotag™ RPA1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | RPA1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | RPA1 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | POLR1A |
| Accession No. | O95602 O35134 O54889 |
| Description | RNA polymerase I subunit A(POLR1A) Homo sapiens The protein encoded by this gene is the largest subunit of the RNA polymerase I complex. The encoded protein represents the catalytic subunit of the complex, which transcribes DNA into ribosomal RNA precursors. Defects in this gene are a cause of the Cincinnati type of acrofacial dysostosis. [provided by RefSeq, May 2016], |
| Cell Pathway/ Category | Purine metabolism,Pyrimidine metabolism,RNA polymerase, |
| Protein Expression | Colon,Skin,Uterus, |
| Subcellular Localization | nucleus,nucleoplasm,nucleolus,DNA-directed RNA polymerase I complex,cytoplasm, |
| Protein Function | catalytic activity:Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).,function:DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.,PTM:Phosphorylated.,similarity:Belongs to the RNA polymerase beta' chain family.,subunit:Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits. Interacts with MYO1C., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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