ITN0692
ITN0692
- Catalog: ITN0692
- Gene/Protein: UBR2 C6orf133 KIAA0349
- Product Description: Immunotag™ UBR2 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | UBR2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | UBR2 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | UBR2 C6orf133 KIAA0349 |
| Accession No. | Q8IWV8 Q6WKZ8 |
| Description | ubiquitin protein ligase E3 component n-recognin 2(UBR2) Homo sapiens This gene encodes an E3 ubiquitin ligase of the N-end rule proteolytic pathway that targets proteins with destabilizing N-terminal residues for polyubiquitylation and proteasome-mediated degradation. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010], |
| Protein Expression | Brain,Ovary,Testis, |
| Subcellular Localization | ubiquitin ligase complex,chromatin,nucleoplasm,cytoplasm,cytosol,plasma membrane, |
| Protein Function | developmental stage:Expressed in fetal pancreas.,domain:The RING-H2 zinc finger is an atypical RING finger with a His ligand in place of the fourth Cys of the classical motif.,function:E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the UBR1 family.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 1 UBR-type zinc finger.,subunit:Interacts with UBE2B (By similarity). Interacts with RECQL4.,tissue specificity:Broadly expressed, with highest levels in skeletal muscle, kidney and pancreas. Present in acinar cells of the pancreas (at protein level)., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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