ITN0705
ITN0705
- Catalog: ITN0705
- Gene/Protein: HSD17B1 E17KSR EDH17B1 EDH17B2 EDHB17
- Product Description: Immunotag™ DHB1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | DHB1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | DHB1 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | HSD17B1 E17KSR EDH17B1 EDH17B2 EDHB17 |
| Accession No. | P14061 P51656 P51657 |
| Description | hydroxysteroid 17-beta dehydrogenase 1(HSD17B1) Homo sapiens This gene encodes a member of the 17beta-hydroxysteroid dehydrogenase family of short-chain dehydrogenases/reductases. It has a dual function in estrogen activation and androgen inactivation and plays a major role in establishing the estrogen E2 concentration gradient between serum and peripheral tissues. The encoded protein catalyzes the last step in estrogen activation, using NADPH to convert estrogens E1 and E2 and androgens like 4-androstenedione, to testosterone. It has an N-terminal short-chain dehydrogenase domain with a cofactor binding site, and a narrow, hydrophobic C-terminal domain with a steroid substrate binding site. This gene is expressed primarily in the placenta and ovarian granulosa cells, and to a lesser extent, in the endometrium, adipose tissue, and prostate. Polymorphisms in this gene have been linked to breast and prostate cancer. A pseudogene of this gene has |
| Cell Pathway/ Category | Steroid hormone biosynthesis,Androgen and estrogen metabolism, |
| Protein Expression | Brain,Placenta,Skin, |
| Subcellular Localization | nucleoplasm,cytoplasm,cytosol,nuclear membrane, |
| Protein Function | catalytic activity:Estradiol-17-beta + NAD(P)(+) = estrone + NAD(P)H.,function:Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.,online information:The Singapore human mutation and polymorphism database,pathway:Steroid biosynthesis; estrogen biosynthesis.,similarity:Belongs to the short-chain dehydrogenases/reductases (SDR) family.,subunit:Homodimer., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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