ITN0768
ITN0768
- Catalog: ITN0768
- Gene/Protein: HESX1 HANF
- Product Description: Immunotag™ HESX1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | HESX1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | HESX1 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | HESX1 HANF |
| Accession No. | Q9UBX0 Q61658 |
| Description | HESX homeobox 1(HESX1) Homo sapiens This gene encodes a conserved homeobox protein that is a transcriptional repressor in the developing forebrain and pituitary gland. Mutations in this gene are associated with septooptic dysplasia, HESX1-related growth hormone deficiency, and combined pituitary hormone deficiency. [provided by RefSeq, Jul 2008], |
| Protein Expression | Fibrosarcoma,Teratocarcinoma, |
| Subcellular Localization | nucleus, |
| Protein Function | developmental stage:Strongly expressed in Rathke pouch in seven-week-old embryo.,disease:Defects in HESX1 are a cause of septooptic dysplasia (SOD) [MIM:182230]; also known as de Morsier syndrome. SOD is a rare autosomal recessive disease. SOD is characterized by optic nerve hypoplasia, absence of the corpus callosum and hypoplasia of the pituitary gland with panhypopopituitarism.,disease:Defects in HESX1 are associated with pituitary dwarfism III [MIM:262600]; also known as combined pituitary hormone deficiency (CPHD). This syndrome is manifested by deficiencies in anterior pituitary tropic hormones.,function:Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation.,similarity:Belongs to the ANF homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,subunit:Can form heterodimers with PROP1 in binding to DNA (By similarity). Interacts with TLE1., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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