ITN0796
ITN0796
- Catalog: ITN0796
- Gene/Protein: TGIF2
- Product Description: Immunotag™ TGIF2 Polyclonal Antibody
385.0000
Price in reward points: 385
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Antibody Specification | |
Datasheet | |
Target Protein | TGIF2 |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,ELISA |
Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
Concentration | 1 mg/ml |
Reactive Species | Human,Mouse |
Host Species | Rabbit |
Immunogen | Synthesized peptide derived from part region of human protein |
Specificity | TGIF2 Polyclonal Antibody detects endogenous levels of protein. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
Gene Name | TGIF2 |
Accession No. | Q9GZN2 Q8C0Y1 |
Description | TGFB induced factor homeobox 2(TGIF2) Homo sapiens The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 (chromosome 20 open reading frame 24) gene. [provided by RefSeq, Dec 2010], |
Protein Expression | Muscle,Ovarian carcinoma, |
Subcellular Localization | nucleus,nucleoplasm, |
Protein Function | function:Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins.,miscellaneous:TGIF2 is amplified and overexpressed in several ovarian cancer cell lines.,PTM:The C-terminal part is phosphorylated in response to EGF signaling by the Ras/MAPK pathway.,similarity:Belongs to the TALE/TGIF homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,subcellular location:Excluded from nucleoli.,subunit:Interacts with the transcriptional modulator SMAD3 and the histone deacetylase HDAC1.,tissue specificity:Widely expressed. Highly expressed in heart, kidney and testis. Weakly expressed in brain and prostate., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |