ITN0800
ITN0800
- Catalog: ITN0800
- Gene/Protein: HAP1 HAP2 HLP1
- Product Description: Immunotag™ HAP1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | HAP1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Rat,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | HAP1 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | HAP1 HAP2 HLP1 |
| Accession No. | P54257 O35668 P54256 |
| Description | huntingtin associated protein 1(HAP1) Homo sapiens Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Huntington's disease, |
| Protein Expression | Brain,Caudate nucleus,Embryo, |
| Subcellular Localization | nucleus,mitochondrion,lysosome,autophagosome,endoplasmic reticulum,centriole,cytoskeleton,synaptic vesicle,actin cytoskeleton,inclusion body,cell junction,axon cytoplasm, |
| Protein Function | Additional isoforms seem to exist,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,function:Associates specifically with huntingtin. This binding is enhanced by an expanded polyglutamine repeat.,similarity:Contains 1 HAP1 N-terminal domain.,tissue specificity:Predominantly expressed in brain. Selectively expressed in neurons., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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