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ITN0836

ITN0836
  • Gene/Protein: MARVELD2 TRIC
  • Product Description: Immunotag™ MALD2 Polyclonal Antibody
280.0000
Price in reward points: 294

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Immunotag™ MALD2 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein MALD2
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000
Concentration 1 mg/ml
Reactive Species Human,Mouse
Host Species Rabbit
Immunogen Synthesized peptide derived from human protein . at AA range: 170-250
Specificity MALD2 Polyclonal Antibody detects endogenous levels of protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Gene Name MARVELD2 TRIC
Accession No. Q8N4S9 Q3UZP0
Description MARVEL domain containing 2(MARVELD2) Homo sapiens The protein encoded by this gene is a membrane protein found at the tight junctions between epithelial cells. The encoded protein helps establish epithelial barriers such as those in the organ of Corti, where these barriers are required for normal hearing. Defects in this gene are a cause of deafness autosomal recessive type 49 (DFNB49). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011],
Protein Expression Brain,Epithelium,Lung,Trachea,
Subcellular Localization cytoplasm,bicellular tight junction,integral component of membrane,basolateral plasma membrane,apical plasma membrane,cytoplasmic vesicle,paranodal junction,Schmidt-Lanterman incisure,tricellular tight junction,
Protein Function disease:Defects in MARVELD2 are the cause of non-syndromic sensorineural deafness autosomal recessive type 49 (DFNB49) [MIM:610153]. DFNB49 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.,function:Plays a role in the formation of the epithelial barriers. The separation of the endolymphatic and perilymphatic spaces of the organ of Corti from one another by epithelial barriers is required for normal hearing.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 MARVEL domain.,subcellular location:Found at tricellular contacts.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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