ITN0883
ITN0883
- Catalog: ITN0883
- Gene/Protein: MADCAM1
- Product Description: Immunotag™ MADCA Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | MADCA |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Rat,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein, at AA range: 260-340 |
| Specificity | MADCA Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | MADCAM1 |
| Accession No. | Q13477 Q61826 O70540 |
| Description | mucosal vascular addressin cell adhesion molecule 1(MADCAM1) Homo sapiens The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Cell adhesion molecules (CAMs),Intestinal immune network for IgA production, |
| Protein Expression | Brain,Fetal brain,Lymph node,Placenta,Pooled, |
| Subcellular Localization | plasma membrane,membrane,integral component of membrane, |
| Protein Function | Additional isoforms seem to exist,function:Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.,polymorphism:The number of repeats in the mucin domain varies between 5 and 8 repeats.,PTM:The Ser/Thr-rich mucin-like domain may provide possible sites for O-glycosylation.,similarity:Contains 2 Ig-like (immunoglobulin-like) domains.,subunit:Homodimer.,tissue specificity:Highly expressed on high endothelial venules (HEV) and lamina propia venules found in the small intestine, and to a lesser extent in the colon and spleen. Very low levels of expression found in pancreas and brain. Not expressed in the thymus, prostate, ovaries, testis, heart, placenta, lung, liver, skeletal muscle, kidneys or peripheral blood leukocytes., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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