ITN0885
ITN0885
- Catalog: ITN0885
- Gene/Protein: ABCC1 MRP MRP1
- Product Description: Immunotag™ MRP1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | MRP1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Rat,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein, at AA range: 110-190 |
| Specificity | MRP1 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | ABCC1 MRP MRP1 |
| Accession No. | P33527 O35379 Q8CG09 |
| Description | ATP binding cassette subfamily C member 1(ABCC1) Homo sapiens The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012], |
| Cell Pathway/ Category | ABC transporters, |
| Protein Expression | Amygdala,Brain,Eye, |
| Subcellular Localization | plasma membrane,integral component of plasma membrane,membrane,integral component of membrane,basolateral plasma membrane,extracellular exosome, |
| Protein Function | Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms,function:Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.,similarity:Belongs to the ABC transporter family.,similarity:Belongs to the ABC transporter family. Conjugate transporter (TC 3.A.1.208) subfamily.,similarity:Contains 2 ABC transmembrane type-1 domains.,similarity:Contains 2 ABC transporter domains.,tissue specificity:Lung, testis and peripheral blood mononuclear cells., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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