ITN0896
ITN0896
- Catalog: ITN0896
- Gene/Protein: MDFIC
- Product Description: Immunotag™ MDFIC Polyclonal Antibody
385.0000
Price in reward points: 385
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Antibody Specification | |
Datasheet | |
Target Protein | MDFIC |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,ELISA |
Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
Concentration | 1 mg/ml |
Reactive Species | Human,Mouse |
Host Species | Rabbit |
Immunogen | Synthesized peptide derived from human protein . at AA range: 100-180 |
Specificity | MDFIC Polyclonal Antibody detects endogenous levels of protein. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
Gene Name | MDFIC |
Accession No. | Q9P1T7 Q8BX65 |
Description | MyoD family inhibitor domain containing(MDFIC) Homo sapiens This gene product is a member of a family of proteins characterized by a specific cysteine-rich C-terminal domain, which is involved in transcriptional regulation of viral genome expression. Alternative translation initiation from an upstream non-AUG (GUG), and an in-frame, downstream AUG codon, results in the production of two isoforms, p40 and p32, respectively, which have different subcellular localization; p32 is mainly found in the cytoplasm, whereas p40 is targeted to the nucleolus. Both isoforms have transcriptional regulatory activity that is attributable to the cysteine-rich C-terminal domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009], |
Protein Expression | Leukocyte,T-cell, |
Subcellular Localization | nucleus,nucleoplasm,nucleolus,cytoplasm,Golgi apparatus, |
Protein Function | domain:The cysteine-rich C-terminus is involved in its granular distribution in the cytoplasm.,function:Modulates the expression from both cellular and viral promoters. Down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin-beta. Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways.,similarity:Belongs to the MDFI family.,subcellular location:Isoform 1 localizes to the nucleolus and also shows a granular distribution in the cytoplasm. Isoform 2 is predominantly distributed throughout the cytoplasm, with only weak expression in the nucleus.,subunit:The C-terminus interacts with HIV-1 Tat and Rev, AXIN1, the histidine-rich region of CCNT1/CYCLIN T and weakly with LEF1.,tissue specificity:Expressed in lymphoid organs (spleen, thymus, peripheral blood leukocytes) as well as prostate, uterus and small intestine., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |