ITN0909
ITN0909
- Catalog: ITN0909
- Gene/Protein: MYO7A USH1B
- Product Description: Immunotag™ MYO7A Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | MYO7A |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 830-910 |
| Specificity | MYO7A Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | MYO7A USH1B |
| Accession No. | Q13402 P97479 |
| Description | myosin VIIA(MYO7A) Homo sapiens This gene is a member of the myosin gene family. Myosins are mechanochemical proteins characterized by the presence of a motor domain, an actin-binding domain, a neck domain that interacts with other proteins, and a tail domain that serves as an anchor. This gene encodes an unconventional myosin with a very short tail. Defects in this gene are associated with the mouse shaker-1 phenotype and the human Usher syndrome 1B which are characterized by deafness, reduced vestibular function, and (in human) retinal degeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008], |
| Protein Expression | Epithelium,Leukocyte,Liver,Retina,Spleen,Testis, |
| Subcellular Localization | photoreceptor outer segment,photoreceptor inner segment,cytoplasm,lysosomal membrane,cytosol,cytoskeleton,microvillus,cell cortex,apical plasma membrane,myosin complex,myosin VII complex,photoreceptor connecting cilium,stereo |
| Protein Function | Additional isoforms seem to exist,developmental stage:Detected in optic cup in 5.5 weeks-old embryos. Expressed in retinal pigment epithelium, cochlear and vestibular neuroepithelia, and olfactory epithelium at 8 weeks. At 19 weeks, present in both pigment epithelium and photoreceptor cells. At 24-28 weeks, expression in pigment epithelium and photoreceptor cells increases. Present in pigment epithelium and photoreceptor cells in adult.,disease:Defects in MYO7A are the cause of non-syndromic sensorineural deafness autosomal dominant type 11 (DFNA11) [MIM:601317].,disease:Defects in MYO7A are the cause of non-syndromic sensorineural deafness autosomal recessive type 2 (DFNB2) [MIM:600060]; also called neurosensory non-syndromic recessive deafness 2 (NSRD2). DFNB2 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.,disease:Defects in MYO7A are the cause of Usher syndrome type 1B (USH1B) [MIM:276900]. USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa and sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH1 is characterized by profound congenital sensorineural deafness, absent vestibular function and prepubertal onset of progressive retinitis pigmentosa leading to blindness.,function:Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. In retina, myosin VIIa might play a role in trafficking of ribbon-synaptic vesicle complexes and renewal of the outer photoreceptors disks. In inner ear, it might maintain the rigidity of stereocilia during the dynamic movements of the bundle. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity.,online information:Gene page,online information:Retina International's Scientific Newsletter,similarity:Contains 1 FERM domain.,similarity:Contains 1 myosin head-like domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 2 FERM domains.,similarity:Contains 2 MyTH4 domains.,similarity:Contains 5 IQ domains.,subcellular location:In the photoreceptor cells, mainly localized in the inner and base of outer segments as well as in the synaptic ending region.,subunit:Might homodimerize in a two headed molecule through the formation of a coiled-coil rod. Binds MYRIP and WHRN.,tissue specificity:Expressed in the pigment epithelium and the photoreceptor cells of the retina. Also found in kidney, liver, testis, cochlea, lymphocytes. Not expressed in brain., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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