ITN0913
ITN0913
- Catalog: ITN0913
- Gene/Protein: MYO18B
- Product Description: Immunotag™ MY18B Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | MY18B |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p |
| Recommended Dilution | IHC-p 1:50-300 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 1680-1760 |
| Specificity | MY18B Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | MYO18B |
| Accession No. | Q8IUG5 |
| Description | myosin XVIIIB(MYO18B) Homo sapiens The protein encoded by this gene may regulate muscle-specific genes when in the nucleus and may influence intracellular trafficking when in the cytoplasm. The encoded protein functions as a homodimer and may interact with F actin. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jul 2008], |
| Protein Expression | Epithelium,Heart,Liver,Platelet,Skeletal muscle,Testis, |
| Subcellular Localization | nucleus,nucleoplasm,centrosome,myosin complex,unconventional myosin complex,sarcomere,Z disc,filamentous actin, |
| Protein Function | developmental stage:Reaches an expression peak in the third day after induction and remains at similar level during successive myotubule maturation.,disease:Defects in MYO18B are associated with lung cancer. Inactivated in half of the primary lung cancers and cell lines; the causes include deletions, mutations and promoter methylation.,function:May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play an important role as a tumor suppressor in the development of lung cancer.,similarity:Contains 1 IQ domain.,similarity:Contains 1 myosin head-like domain.,subcellular location:Punctate pattern in undifferentiated myoblasts. Nuclear, on primary cardiomyocytes and adult muscle. A partial sarcomeric location was found in some cardiomyocytes.,subunit:Homodimer. May interact with F actin through the GPA motif (Gly/Pro/Ala-rich).,tissue specificity:Selectively expressed in cardiac and skeletal muscles. Weakly expressed in testis, pancreas, placenta, prostate, lung and thymus., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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