ITN0934
ITN0934
- Catalog: ITN0934
- Gene/Protein: NDUFS8
- Product Description: Immunotag™ NDUS8 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | NDUS8 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 90-170 |
| Specificity | NDUS8 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | NDUFS8 |
| Accession No. | O00217 Q8K3J1 |
| Description | NADH:ubiquinone oxidoreductase core subunit S8(NDUFS8) Homo sapiens This gene encodes a subunit of mitochondrial NADH:ubiquinone oxidoreductase, or Complex I, a multimeric enzyme of the respiratory chain responsible for NADH oxidation, ubiquinone reduction, and the ejection of protons from mitochondria. The encoded protein is involved in the binding of two of the six to eight iron-sulfur clusters of Complex I and, as such, is required in the electron transfer process. Mutations in this gene have been associated with Leigh syndrome. [provided by RefSeq, Mar 2010], |
| Cell Pathway/ Category | Oxidative phosphorylation,Alzheimer's disease,Parkinson's disease,Huntington's disease, |
| Protein Expression | PCR rescued clones,Uterus, |
| Subcellular Localization | mitochondrion,mitochondrial respiratory chain complex I,mitochondrial matrix,membrane, |
| Protein Function | catalytic activity:NADH + acceptor = NAD(+) + reduced acceptor.,catalytic activity:NADH + ubiquinone = NAD(+) + ubiquinol.,cofactor:Binds 2 4Fe-4S clusters per subunit.,disease:Defects in NDUFS8 are a cause of Leigh syndrome (LS) [MIM:256000]. LS is a severe neurological disorder characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions.,function:Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). May donate electrons to ubiquinone.,similarity:Belongs to the complex I 23 kDa subunit family.,similarity:Contains 2 4Fe-4S ferredoxin-type domains.,subunit:Mammalian complex I is composed of 45 different subunits., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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