ITN0943
ITN0943
- Catalog: ITN0943
- Gene/Protein: SYNE2 KIAA1011 NUA
- Product Description: Immunotag™ SYNE2 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | SYNE2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p |
| Recommended Dilution | IHC-p 1:50-300 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 360-440 |
| Specificity | SYNE2 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | SYNE2 KIAA1011 NUA |
| Accession No. | Q8WXH0 Q6ZWQ0 |
| Description | spectrin repeat containing nuclear envelope protein 2(SYNE2) Homo sapiens The protein encoded by this gene is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009], |
| Protein Expression | Brain,Epithelium,Human fetal brain,Human retina,Spl |
| Subcellular Localization | nucleus,nuclear envelope,nuclear outer membrane,nucleoplasm,cytoplasm,mitochondrion,focal adhesion,integral component of membrane,aggresome,sarcoplasmic reticulum,Z disc,lamellipodium membrane, |
| Protein Function | domain:The Klarsicht domain mediates the nuclear envelope targeting.,function:Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which theters the nucleus to the cytoskeleton. Connects nuclei to the cytoskeleton by interacting with the nuclear envelope and with F-actin in the cytoplasm.,similarity:Belongs to the nesprin family.,similarity:Contains 1 actin-binding domain.,similarity:Contains 1 KASH domain.,similarity:Contains 13 LRR (leucine-rich) repeats.,similarity:Contains 2 CH (calponin-homology) domains.,similarity:Contains 9 spectrin repeats.,subcellular location:The largest part of the protein is cytoplasmic, while its C-terminal part is associated with the nuclear envelope, most probably the outer nuclear membrane. Remains associated with the nuclear envelope during its breakdown in mitotic cells.,subunit:Interacts with F-actin via its N-terminal domain.,tissue specificity:Widely expressed, with higher level in kidney, adult and fetal liver, stomach and placenta. Weakly expressed in skeletal muscle and brain. Isoform 5 is highly expressed in pancreas, skeletal muscle and heart., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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