ITN0944
ITN0944
- Catalog: ITN0944
- Gene/Protein: UNC5A KIAA1976 UNC5H1
- Product Description: Immunotag™ UNC5A Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | UNC5A |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein, at AA range: 130-210 |
| Specificity | UNC5A Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | UNC5A KIAA1976 UNC5H1 |
| Accession No. | Q6ZN44 Q8K1S4 O08721 |
| Description | unc-5 netrin receptor A(UNC5A) Homo sapiens UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).[supplied by OMIM, Apr 2004], |
| Cell Pathway/ Category | Axon guidance, |
| Protein Expression | Brain,PCR rescued clones,Pooled, |
| Subcellular Localization | plasma membrane,integral component of membrane,intrinsic component of plasma membrane,neuron projection membrane,neuronal cell body membrane,membrane raft, |
| Protein Function | domain:The ZU5 domain mediates the interaction with MAGED1, which participates in the induction of apoptosis.,function:Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.,induction:By p53/TP53.,miscellaneous:Down-regulated in multiple cancers including colorectal, breast, ovary, uterus, stomach, lung, or kidney cancers.,PTM:Phosphorylated on cytoplasmic tyrosine residues. Phosphorylated by PKC in vitro.,PTM:Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.,sequence caution:Intron retention.,similarity:Belongs to the unc-5 family.,similarity:Contains 1 death domain.,similarity:Contains 1 Ig-like (immunoglobulin-like) domain.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 TSP type-1 domain.,similarity:Contains 1 ZU5 domain.,subcellular location:The interaction with PRKCABP regulates its surface expression and leads to its removal from surface of neurons and growth cones.,subunit:Interacts with the cytoplasmic part of DCC. Interacts with MAGED1. Interacts with PRKCABP, possibly mediating some interaction with PKC., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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