ITN0967
ITN0967
- Catalog: ITN0967
- Gene/Protein: NLGN3 KIAA1480 NL3
- Product Description: Immunotag™ NLGN3 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | NLGN3 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein, at AA range: 610-690 |
| Specificity | NLGN3 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | NLGN3 KIAA1480 NL3 |
| Accession No. | Q9NZ94 Q8BYM5 Q62889 |
| Description | neuroligin 3(NLGN3) Homo sapiens This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Oct 2009], |
| Cell Pathway/ Category | Cell adhesion molecules (CAMs), |
| Protein Expression | Brain,Human fetal brain, |
| Subcellular Localization | extracellular space,integral component of plasma membrane,cell surface,integral component of membrane,cell junction,endocytic vesicle,synapse,excitatory synapse,postsynapse,integral component of postsynaptic membrane, |
| Protein Function | disease:Defects in NLGN3 may be the cause of susceptibility to X-linked Asperger syndrome 1 (ASPGX1) [MIM:300494]. ASPGX1 is considered to be a form of childhood autism.,disease:Defects in NLGN3 may be the cause of susceptibility to X-linked autism 1 (AUTSX1) [MIM:300425]. AUTSX1 is a pervasive developmental disorder (PDD), prototypically characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age.,function:Neuronal cell surface protein thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins. May play a role in formation or maintenance of synaptic junctions. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the type-B carboxylesterase/lipase family.,subunit:Interacts with neurexin 1-beta, neurexin 2-beta and neurexin 3-beta (By similarity). Probably interacts through its C-terminus with DLG4/PSD-95 third PDZ domain., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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