ITN0996
ITN0996
- Catalog: ITN0996
- Gene/Protein: NUP62
- Product Description: Immunotag™ NUP62 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | NUP62 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Rat,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein, at AA range: 300-380 |
| Specificity | NUP62 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | NUP62 |
| Accession No. | P37198 Q63850 P17955 |
| Description | nucleoporin 62(NUP62) Homo sapiens The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of this gene encode a single protein isoform. [provided by RefSeq, Jul 2008], |
| Protein Expression | Brain,Pancreas,Skin,Testis,Urinary bladder, |
| Subcellular Localization | spindle pole,nuclear envelope,annulate lamellae,nuclear pore,cytoplasm,intracellular ribonucleoprotein complex,nucleocytoplasmic shuttling complex,nuclear membrane,intracellular membrane-bounded organelle,nuclear pore central transport channel,por |
| Protein Function | disease:Defects in NUP62 are the cause of infantile striatonigral degeneration (SNDI) [MIM:271930]; also known as infantile bilateral striatal necrosis (IBSN) or infantile bilateral striatal necrosis or familial striatal degeneration. SNDI is a neurological disorder characterized by symmetrical degeneration of the caudate nucleus, putamen, and occasionally the globus pallidus, with little involvement of the rest of the brain. The clinical features include developmental regression, choreoathetosis, dystonia, spasticity, dysphagia, failure to thrive, nystagmus, optic atrophy, and mental retardation.,domain:Contains F-X-F-G repeats.,function:Essential component of the nuclear pore complex. The N-terminal is probably involved in nucleocytoplasmic transport. The C-terminal is probably involved in protein-protein interaction via coiled-coil formation and may function in anchorage of p62 to the pore complex.,PTM:O-glycosylated. Contains about 10 N-acetylglucosamine side chain sites predicted for the entire protein, amongst which only one in the C-terminal.,similarity:Belongs to the nucleoporin NSP1/NUP62 family.,subcellular location:Central region of the nuclear pore, within the transporter. During mitotic cell division, it associates with the poles of the mitotic spindle.,subunit:Component of the p62 complex, a complex at least composed of NUP62, NUP54, and NUPL1., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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