ITN1030
ITN1030
ITN1030
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- Catalog: ITN1030
- Gene/Protein: PCM1
- Product Description: Immunotag™ PCM1 Polyclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein PCM1 Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,ELISA Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000 Concentration 1 mg/ml Reactive Species Human,Mouse Host Species Rabbit Immunogen Synthesized peptide derived from human protein . at AA range: 140-220 Specificity PCM1 Polyclonal Antibody detects endogenous levels of protein. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. Gene Name PCM1 Accession No. Q15154 Q9R0L6 Description pericentriolar material 1(PCM1) Homo sapiens The protein encoded by this gene is a component of centriolar satellites, which are electron dense granules scattered around centrosomes. Inhibition studies show that this protein is essential for the correct localization of several centrosomal proteins, and for anchoring microtubules to the centrosome. Chromosomal aberrations involving this gene are associated with papillary thyroid carcinomas and a variety of hematological malignancies, including atypical chronic myeloid leukemia and T-cell lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015], Protein Expression Brain,Epithelium,Liver,Lung,PCR rescued clones,Testis,Uterus, Subcellular Localization pericentriolar material,cytoplasm,centrosome,centriole,cytosol,membrane,nuclear membrane,centriolar satellite,ciliary transition zone,ciliary basal body,protein complex,apical part of cell, Protein Function disease:A chromosomal aberration involving PCM1 is found in a variety of hematological malignancies including atypical chronic myeloid leukemia (atypical CML) and T-cell lymphoma. Translocation t(8;9)(p22;p24) with JAK2 links the protein kinase domain of JAK2 to the major portion of PCM1.,disease:A chromosomal aberration involving PCM1 is found in thyroid papillary carcinoma (PACT) [MIM:188550]. Translocation t(8;10)(p21.3;q11.2) with RET links the protein kinase domain of RET to the major portion of PCM1.,function:Required for centrosome assembly and function. Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2. Required to anchor microtubules to the centrosome.,induction:Expression is reduced in breast and ovarian cancer.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the PCM1 family.,subcellular location:Localizes to cytoplasmic granules which are enriched around the centrosome. This centrosomal enrichment requires microtubules and dynein. The majority of the protein dissociates from the centrosome during metaphase and subsequently localizes to the cleavage site in telophase.,subunit:Self-associates (By similarity). Interacts with BBS4, BBS8, CETN3, HAP1, NDE1 and NDEL1.,tissue specificity:Expressed in blood, bone marrow, breast, lymph node, ovary and thyroid., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | PCM1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 140-220 |
| Specificity | PCM1 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | PCM1 |
| Accession No. | Q15154 Q9R0L6 |
| Description | pericentriolar material 1(PCM1) Homo sapiens The protein encoded by this gene is a component of centriolar satellites, which are electron dense granules scattered around centrosomes. Inhibition studies show that this protein is essential for the correct localization of several centrosomal proteins, and for anchoring microtubules to the centrosome. Chromosomal aberrations involving this gene are associated with papillary thyroid carcinomas and a variety of hematological malignancies, including atypical chronic myeloid leukemia and T-cell lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015], |
| Protein Expression | Brain,Epithelium,Liver,Lung,PCR rescued clones,Testis,Uterus, |
| Subcellular Localization | pericentriolar material,cytoplasm,centrosome,centriole,cytosol,membrane,nuclear membrane,centriolar satellite,ciliary transition zone,ciliary basal body,protein complex,apical part of cell, |
| Protein Function | disease:A chromosomal aberration involving PCM1 is found in a variety of hematological malignancies including atypical chronic myeloid leukemia (atypical CML) and T-cell lymphoma. Translocation t(8;9)(p22;p24) with JAK2 links the protein kinase domain of JAK2 to the major portion of PCM1.,disease:A chromosomal aberration involving PCM1 is found in thyroid papillary carcinoma (PACT) [MIM:188550]. Translocation t(8;10)(p21.3;q11.2) with RET links the protein kinase domain of RET to the major portion of PCM1.,function:Required for centrosome assembly and function. Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2. Required to anchor microtubules to the centrosome.,induction:Expression is reduced in breast and ovarian cancer.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the PCM1 family.,subcellular location:Localizes to cytoplasmic granules which are enriched around the centrosome. This centrosomal enrichment requires microtubules and dynein. The majority of the protein dissociates from the centrosome during metaphase and subsequently localizes to the cleavage site in telophase.,subunit:Self-associates (By similarity). Interacts with BBS4, BBS8, CETN3, HAP1, NDE1 and NDEL1.,tissue specificity:Expressed in blood, bone marrow, breast, lymph node, ovary and thyroid., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |