ITN1067
ITN1067
- Catalog: ITN1067
- Gene/Protein: PLXNA2 KIAA0463 OCT PLXN2 UNQ209/PRO235
- Product Description: Immunotag™ PLXA2 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | PLXA2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 600-680 |
| Specificity | PLXA2 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | PLXNA2 KIAA0463 OCT PLXN2 UNQ209/PRO235 |
| Accession No. | O75051 P70207 |
| Description | plexin A2(PLXNA2) Homo sapiens This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Axon guidance, |
| Protein Expression | Brain,Liver,Placenta,Skeletal muscle,Tongue,Whole embryo, |
| Subcellular Localization | semaphorin receptor complex,plasma membrane,integral component of plasma membrane, |
| Protein Function | function:Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.,similarity:Belongs to the plexin family.,similarity:Contains 1 Sema domain.,similarity:Contains 4 IPT/TIG domains.,subunit:Interacts directly with NRP1 and NRP2.,tissue specificity:Detected in fetal brain., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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