ITN1214
ITN1214
- Catalog: ITN1214
- Gene/Protein: ARHGAP24 FILGAP
- Product Description: Immunotag™ RHG24 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | RHG24 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Rat,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein, at AA range: 550-630 |
| Specificity | RHG24 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | ARHGAP24 FILGAP |
| Accession No. | Q8N264 Q8C4V1 Q5U2Z7 |
| Description | Rho GTPase activating protein 24(ARHGAP24) Homo sapiens This gene encodes a Rho-GTPase activating protein, which is specific for the small GTPase family member Rac. Binding of the encoded protein by filamin A targets it to sites of membrane protrusion, where it antognizes Rac. This results in suppression of lamellae formation and promotion of retraction to regulate cell polarity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016], |
| Protein Expression | Brain,Chondrosarcoma,Spleen,Tongue, |
| Subcellular Localization | cytosol,cytoskeleton,focal adhesion,cell projection, |
| Protein Function | domain:The coiled coil domain mediates the interaction with FLNA leading to its recruitment to lamellae.,function:Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis.,induction:Isoform 2 is up-regulated during capillary tube formation in umbilical vein endothelial cells.,PTM:Phosphorylated by ROCK, leading to activate the RacGAP activity.,similarity:Contains 1 PH domain.,similarity:Contains 1 Rho-GAP domain.,subcellular location:Localizes to actin stress fibers. In migrating cells, localizes to membrane lamellae and protusions.,subunit:Interacts with FLNA.,tissue specificity:Isoform 1 is widely expressed with a higher level in kidney. Isoform 2 is mainly expressed in endothelial cells., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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