ITN1244
ITN1244
- Catalog: ITN1244
- Gene/Protein: CROCC KIAA0445
- Product Description: Immunotag™ CROCC Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | CROCC |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 220-300 |
| Specificity | CROCC Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | CROCC KIAA0445 |
| Accession No. | Q5TZA2 Q8CJ40 |
| Description | function:Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus. Contributes to centrosome cohesion before mitosis.,PTM:Phosphorylated by NEK2 which may regulate its association with centrosomes. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the rootletin family.,subcellular location:In ciliated cells, associated with ciliary rootlets. In non-ciliated cells, localized between, around and at the proximal ends of the centrioles. Dissociates from the centrioles at the onset of mitosis and reassociates with them at anaphase.,subunit:Homopolymer. Interacts with KLC3, NEK2 and the N-terminus of CEP250., |
| Protein Expression | Brain,Medulloblastoma, |
| Subcellular Localization | photoreceptor inner segment,cytoplasm,centrosome,centriole,plasma membrane,actin cytoskeleton,ciliary rootlet,extracellular exosome, |
| Protein Function | function:Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus. Contributes to centrosome cohesion before mitosis.,PTM:Phosphorylated by NEK2 which may regulate its association with centrosomes. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the rootletin family.,subcellular location:In ciliated cells, associated with ciliary rootlets. In non-ciliated cells, localized between, around and at the proximal ends of the centrioles. Dissociates from the centrioles at the onset of mitosis and reassociates with them at anaphase.,subunit:Homopolymer. Interacts with KLC3, NEK2 and the N-terminus of CEP250., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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