ITN1306
ITN1306
- Catalog: ITN1306
- Gene/Protein: SH3BP4 BOG25 EHB10 TTP
- Product Description: Immunotag™ SH3B4 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | SH3B4 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Rat,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | SH3B4 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | SH3BP4 BOG25 EHB10 TTP |
| Accession No. | Q9P0V3 Q921I6 Q9JJS5 |
| Description | SH3 domain binding protein 4(SH3BP4) Homo sapiens This gene encodes a protein with 3 Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site. This protein is involved in cargo-specific control of clathrin-mediated endocytosis, specifically controlling the internalization of a specific protein receptor. [provided by RefSeq, Jul 2008], |
| Protein Expression | Corneal fibroblast,Epithelium,Eye,Fibroblast,Placenta, |
| Subcellular Localization | nucleus,cytoplasm,clathrin-coated pit,clathrin-coated vesicle,extracellular exosome, |
| Protein Function | domain:The SH3 domain mediates localization to the clathrin-coated pits and vesicles. The SH3 domain mediates interaction with DNM2 and the cytoplasmic part of TFRC with a lower affinity.,function:Functions in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis.,miscellaneous:Overexpression or depletion of SH3BP4 result in a specific decrease of the transferrin receptor endocytosis that can be rescued by DNM2 overexpression.,PTM:Phosphorylated upon EGF stimulation. Phosphorylation prevents interaction with DNM2.,similarity:Contains 1 SH3 domain.,subcellular location:Specifically associated with transferrin receptor-containing clathrin-coated pits and clathrin-coated vesicles. May also localize to the nucleus.,subunit:Homodimer or homooligomer. Interacts with DNM2, EPS15, clathrin, the adapter protein complex 2/AP-2 and TFRC.,tissue specificity:Expressed in all tissues tested with higher expression in pancreas. Expressed by retinal pigment epithelial cells (at protein level)., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
| English_US |
|
| Danish |
|
| Dutch |
|
| English_UK |
|
| French |
|
| German |
|
| Spanish |
|
| Norwegian |
|
| Portuguese |
|
| Finnish |
|
| Swedish |
|
| Polish |
|