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ITN1373

  • Gene/Protein: SOCS4 SOCS7
  • Product Description: Immunotag™ SOCS4 Polyclonal Antibody
  • 280.0000
    Price in reward points: 294

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ITN1373

Immunotag™ SOCS4 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein SOCS4
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000
Concentration 1 mg/ml
Reactive Species Human,Mouse
Host Species Rabbit
Immunogen Synthesized peptide derived from part region of human protein
Specificity SOCS4 Polyclonal Antibody detects endogenous levels of protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Gene Name SOCS4 SOCS7
Accession No. Q8WXH5 Q91ZA6
Description suppressor of cytokine signaling 4(SOCS4) Homo sapiens The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008],
Cell Pathway/ Category Jak_STAT,Insulin_Receptor,Type II diabetes mellitus,
Protein Expression Endometrium carcinoma cell line,Neuroblastoma,Placenta,
Subcellular Localization intracellular,cytoplasm,
Protein Function domain:The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.,function:SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SOCS box domain.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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