ITN1397
ITN1397
- Catalog: ITN1397
- Gene/Protein: TAPBP NGS17 TAPA
- Product Description: Immunotag™ TPSN Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | TPSN |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | TPSN Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | TAPBP NGS17 TAPA |
| Accession No. | O15533 Q9R233 |
| Description | TAP binding protein(TAPBP) Homo sapiens This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Antigen processing and presentation, |
| Protein Expression | B-cell,Liver,Lymphoblast,Lymphocyte,Neutrophil,Prostate,Skin, |
| Subcellular Localization | Golgi membrane,endoplasmic reticulum,endoplasmic reticulum membrane,membrane,integral component of membrane,MHC class I peptide loading complex,TAP complex,integral component of lumenal side of endoplasmic reticulum membrane, |
| Protein Function | domain:The N-terminus is required for efficient association with MHC class I molecule and for a stable interaction between MHC I and calreticulin. Binding to TAP is mediated by the C-terminus region.,function:Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading).,online information:TAPBP mutation db,polymorphism:The 2 alleles of TAPBP; TAPBP*01 (Tapasin*01) (shown here) and TAPBP*02 (Tapasin*02); are in linkage disequilibria with the HLA-DRB1 locus in a Japanese population.,similarity:Contains 1 Ig-like C1-type (immunoglobulin-like) domain.,subunit:Interacts with TAP1 and is thus a subunit of the TAP complex. Interaction with TAP1 is TAP2 independent and is required for efficient peptide-TAP interaction. Obligatory mediator for the interaction between newly assembled MHC class I molecules, clareticulin, ERp57 and TAP. Up to 4 MHC class I/tapasin complexes bind to 1 TAP.,tissue specificity:Neutrophils, mostly in fully differentiated cells., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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