ITN1446
ITN1446
- Catalog: ITN1446
- Gene/Protein: EIF2B2 EIF2BB
- Product Description: Immunotag™ EI2BB Polyclonal Antibody
385.0000
Price in reward points: 385
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Antibody Specification | |
Datasheet | |
Target Protein | EI2BB |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,ELISA |
Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
Concentration | 1 mg/ml |
Reactive Species | Human,Mouse,Rat |
Host Species | Rabbit |
Immunogen | Synthesized peptide derived from human protein, at AA range: 50-130 |
Specificity | EI2BB Polyclonal Antibody detects endogenous levels of protein. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
Gene Name | EIF2B2 EIF2BB |
Accession No. | P49770 Q99LD9 Q62818 |
Description | eukaryotic translation initiation factor 2B subunit beta(EIF2B2) Homo sapiens This gene encodes the beta subunit of eukaryotic initiation factor-2B (EIF2B). EIF2B is involved in protein synthesis and exchanges GDP and GTP for its activation and deactivation. [provided by RefSeq, Aug 2011], |
Protein Expression | Brain,Lung,Placenta, |
Subcellular Localization | cytoplasm,cytosol,eukaryotic translation initiation factor 2B complex, |
Protein Function | disease:Defects in EIF2B2 are a cause of leukodystrophy with vanishing white matter (VWM) [MIM:603896]. VWM is a leukodystrophy that occurs mainly in children. Neurological signs include progressive cerebellar ataxia, spasticity, inconstant optic atrophy and relatively preserved mental abilities. The disease is chronic-progressive with, in most individuals, additional episodes of rapid deterioration following febrile infections or minor head trauma. While childhood onset is the most common form of the disorder, some severe forms are apparent at birth. A severe, early-onset form seen among the Cree and Chippewayan populations of Quebec and Manitoba is called Cree leukoencephalopathy. Milder forms may not become evident until adolescence or adulthood. Some females with milder forms of the disease who survive to adolescence exhibit ovarian dysfunction. This variant of the disorder is called ovarioleukodystrophy.,function:Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.,similarity:Belongs to the EIF-2B alpha/beta/delta subunits family.,subunit:Complex of five different subunits; alpha, beta, gamma, delta and epsilon., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |