ITN1463
ITN1463
- Catalog: ITN1463
- Gene/Protein: USP1
- Product Description: Immunotag™ UBP1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | UBP1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | UBP1 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | USP1 |
| Accession No. | O94782 Q8BJQ2 Q569C3 |
| Description | ubiquitin specific peptidase 1(USP1) Homo sapiens This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008], |
| Protein Expression | Brain,Epithelium,Eye,Fetal brain,Testis,Uterus, |
| Subcellular Localization | nucleus,nucleoplasm, |
| Protein Function | catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,developmental stage:Cell cycle-regulated. Highest level during S phase.,function:Negative regulator of DNA damage repair. Autocatalytic cleavage of USP1 leads to an increase in ubiquitinated PCNA, recruitment of POLH and translesion synthesis following DNA damage. Regulates ubiquitination of FANCD2.,miscellaneous:HEK293T cells expressing reduced levels of USP1 show a higher level of ubiquitinated PCNA and an increase in point mutations upon UV irradiation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,PTM:Ubiquitinated. Degraded by the proteasome.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the peptidase C19 family.,subunit:Interacts with FANCD2., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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