ITN1480
ITN1480
- Catalog: ITN1480
- Gene/Protein: UFD1L
- Product Description: Immunotag™ UFD1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | UFD1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Rat,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | UFD1 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | UFD1L |
| Accession No. | Q92890 P70362 Q9ES53 |
| Description | ubiquitin fusion degradation 1 like (yeast)(UFD1L) Homo sapiens The protein encoded by this gene forms a complex with two other proteins, nuclear protein localization-4 and valosin-containing protein, and this complex is necessary for the degradation of ubiquitinated proteins. In addition, this complex controls the disassembly of the mitotic spindle and the formation of a closed nuclear envelope after mitosis. Mutations in this gene have been associated with Catch 22 syndrome as well as cardiac and craniofacial defects. Alternative splicing results in multiple transcript variants encoding different isoforms. A related pseudogene has been identified on chromosome 18. [provided by RefSeq, Jun 2009], |
| Protein Expression | Brain,Epithelium,Heart,Skin, |
| Subcellular Localization | nucleus,nucleoplasm,cytosol,VCP-NPL4-UFD1 AAA ATPase complex,UFD1-NPL4 complex, |
| Protein Function | caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,disease:UFD1L gene hemizygosity is the cause of some of the catch 22-associated developmental defects whose notable examples are the DiGeorge syndrome (DGS), the velo-cardio-facial syndrome (VCFS) and the Opitz G/BBB syndrome.,function:Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures.,pathway:Protein degradation; proteasomal ubiquitin-dependent pathway.,similarity:Belongs to the UFD1 family.,subunit:Heterodimer with NPLOC4, this heterodimer binds VCP and inhibits Golgi membrane fusion.,tissue specificity:Found in adult heart, skeletal muscle and pancreas, and in fetal liver and kidney., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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