ITN1483
ITN1483
- Catalog: ITN1483
- Gene/Protein: UBA6 MOP4 UBE1L2
- Product Description: Immunotag™ UBA6 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | UBA6 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | UBA6 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | UBA6 MOP4 UBE1L2 |
| Accession No. | A0AVT1 Q8C7R4 |
| Description | ubiquitin like modifier activating enzyme 6(UBA6) Homo sapiens Modification of proteins with ubiquitin (UBB; MIM 191339) or ubiquitin-like proteins controls many signaling networks and requires a ubiquitin-activating enzyme (E1), a ubiquitin conjugating enzyme (E2), and a ubiquitin protein ligase (E3). UBE1L2 is an E1 enzyme that initiates the activation and conjugation of ubiquitin-like proteins (Jin et al., 2007 [PubMed 17597759]).[supplied by OMIM, Mar 2008], |
| Cell Pathway/ Category | Ubiquitin mediated proteolysis, |
| Protein Expression | Blood,Brain,Hippocampus,Skeletal muscle, |
| Subcellular Localization | cytoplasm,cytosol,integral component of membrane, |
| Protein Function | Named isoforms=3,function:Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the ubiquitin-activating E1 family.,tissue specificity:Widely expressed. Isoform 2 is predominantly expressed in testis with higher expression in adult testis than in fetal testis., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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