ITN1502
ITN1502
- Catalog: ITN1502
- Gene/Protein: UBXN4 KIAA0242 UBXD2 UBXDC1
- Product Description: Immunotag™ UBXN4 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | UBXN4 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Rat,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | UBXN4 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | UBXN4 KIAA0242 UBXD2 UBXDC1 |
| Accession No. | Q92575 Q8VCH8 Q5HZY0 |
| Description | UBX domain protein 4(UBXN4) Homo sapiens UBXD2 is an integral membrane protein of the endoplasmic reticulum (ER) that binds valosin-containing protein (VCP; MIM 601023) and promotes ER-associated protein degradation (ERAD) (Liang et al., 2006 [PubMed 16968747]).[supplied by OMIM, Mar 2008], |
| Protein Expression | Bone marrow,Brain,Eye,Trachea, |
| Subcellular Localization | nuclear envelope,cytoplasm,endoplasmic reticulum,endoplasmic reticulum membrane, |
| Protein Function | domain:The transmembrane domain also contains the signal for ER targeting.,domain:The UBX domain is required for interaction with VCP.,function:Involved in endoplasmic reticulum-associated protein degradation (ERAD).,induction:By ER stress-inducing reagents, such as tunicamycin, thapsigargin, DTT and the calcium ionophore A23187 (at protein level).,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 UBX domain.,subcellular location:Both the N- and the C-terminus face the cytosol; also found in the nucleus envelope contiguous to the ER.,subunit:Directly interacts with VCP.,tissue specificity:Expressed in many tissues, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Accumulates in Alzheimer disease-afflicted brains (at protein level)., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
| English_US |
|
| Danish |
|
| Dutch |
|
| English_UK |
|
| French |
|
| German |
|
| Spanish |
|
| Norwegian |
|
| Portuguese |
|
| Finnish |
|
| Swedish |
|
| Polish |
|