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  • Gene/Protein: ATP6V0A2
  • Product Description: Immunotag™ VPP2 Polyclonal Antibody
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Immunotag™ VPP2 Polyclonal Antibody
Antibody Specification
Target Protein VPP2
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000
Concentration 1 mg/ml
Reactive Species Human
Host Species Rabbit
Immunogen Synthesized peptide derived from part region of human protein
Specificity VPP2 Polyclonal Antibody detects endogenous levels of protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Gene Name ATP6V0A2
Accession No. Q9Y487 P15920
Description ATPase H+ transporting V0 subunit a2(ATP6V0A2) Homo sapiens The protein encoded by this gene is a subunit of the vacuolar ATPase (v-ATPase), an heteromultimeric enzyme that is present in intracellular vesicles and in the plasma membrane of specialized cells, and which is essential for the acidification of diverse cellular components. V-ATPase is comprised of a membrane peripheral V(1) domain for ATP hydrolysis, and an integral membrane V(0) domain for proton translocation. The subunit encoded by this gene is a component of the V(0) domain. Mutations in this gene are a cause of both cutis laxa type II and wrinkly skin syndrome. [provided by RefSeq, Jul 2009],
Cell Pathway/ Category Oxidative phosphorylation,Lysosome,Vibrio cholerae infection,Epithelial cell signaling in Helicobacter pylori infection,
Protein Expression Astrocyte,Epithelium,Placenta,Prostate,
Subcellular Localization vacuolar proton-transporting V-type ATPase, V0 domain,acrosomal vesicle,cytoplasm,lysosomal membrane,plasma membrane,focal adhesion,endosome membrane,integral component of membrane,vacuolar proton-transporting V-type ATPase complex,ph
Protein Function caution:The N-terminus peptide may increase IL1B secretion by peripheral blood monocytes; however as this region is probably in the cytosol, the in vivo relevance of this observation needs to be confirmed.,disease:Defects in ATP6V0A2 are a cause of wrinkly skin syndrome; (WSS) [MIM:278250]. WSS is rare autosomal recessive disorder characterized by wrinkling of the skin of the dorsum of the hands and feet, an increased number of palmar and plantar creases, wrinkled abdominal skin, multiple musculoskeletal abnormalities, microcephaly, growth failure and developmental delay.,disease:Defects in ATP6V0A2 are the cause of cutis laxa type II (ARCL type II) [MIM:219200]. ARCL type II is an autosomal recessive disorder characterized by an excessive congenital skin wrinkling, a large fontanelle with delayed closure, a typical facial appearance with downslanting palpebral fissures, a general connective tissue weakness, and varying degrees of growth and developmental delay and neurological abnormalities. Some affected individuals develop seizures and mental deterioration later in life, whereas the skin phenotype tends to become milder with age. At the molecular level, this disorder belongs to the family of congenital disorders of glycosylation (CDG) and is characterized by the abnormal glycosylation of serum proteins.,function:Part of the proton channel of V-ATPases. Essential component of the endosomal pH-sensing machinery. May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the V-ATPase 116 kDa subunit family.,subcellular location:In kidney proximal tubules, also detected in subapical vesicles.,subunit:The V-ATPase is an heteromultimeric enzyme composed of at least thirteen different subunits. It has a membrane peripheral V1 sector for ATP hydrolysis and an integral V0 for proton translocation. The V1 sector comprises subunits A-H, whereas V0 includes subunits a, d, c, c', and c''. Directly interacts with PSCD2 through its N-terminal cytosolic tail in an intra-endosomal acidification-dependent manner. Disruption of this interaction results in the inhibition of endocytosis.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet

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