ITN1592
ITN1592
- Catalog: ITN1592
- Gene/Protein: SPAG9 HSS KIAA0516 MAPK8IP4 SYD1 HLC6
- Product Description: Immunotag™ JIP4 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | JIP4 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 590-670 |
| Specificity | JIP4 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | SPAG9 HSS KIAA0516 MAPK8IP4 SYD1 HLC6 |
| Accession No. | O60271 Q58A65 |
| Description | sperm associated antigen 9(SPAG9) Homo sapiens This gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011], |
| Protein Expression | Brain,Clones donated by Kazusa DNA Research Inst.,Epithelium,Eye,Kidney,Liv |
| Subcellular Localization | acrosomal vesicle,cytoplasm,microtubule organizing center,cytosol,integral component of membrane,perinuclear region of cytoplasm,extracellular exosome, |
| Protein Function | function:The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Isoform 5 may play a role in spermatozoa-egg-interaction.,induction:Isoform 3 is increased in systemic sclerosis fibroblasts.,PTM:Phosphorylated by MAPK8 and MAPK14 (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the JIP scaffold family.,subcellular location:Associated with the plasma membrane of the acrosomal compartment and also localizes in the acrosome matrix.,subcellular location:Perinuclear distribution in response to stress signals such as UV radiation.,subunit:Homo-oligomer. Interacts with MAX, MAPK8, MAPK9, MAPK10, MAPK14, MAP3K3, MYC, KNS2 and MAP2K4. Interaction with KNS2 is important in the formation of ternary complex with MAPK8. Interacts with NFKB1.,tissue specificity:Isoform 5 is expressed only in testis on the round spermatids of stage I, II and II. Isoform 5 is absent in spermatogonia and spermatocyte. Isoform 3 is expressed in testis. Isoform 4 is expressed in testis and in acute myeloid leukemia (AML) patients., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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