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ITN1702

  • Gene/Protein: TSPYL2 CDA1 DENTT TSPX HRIHFB2216
  • Product Description: Immunotag™ TSYL2 Polyclonal Antibody
  • 280.0000
    Price in reward points: 294

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ITN1702

Immunotag™ TSYL2 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein TSYL2
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000
Concentration 1 mg/ml
Reactive Species Human,Mouse
Host Species Rabbit
Immunogen Synthesized peptide derived from part region of human protein
Specificity TSYL2 Polyclonal Antibody detects endogenous levels of protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Gene Name TSPYL2 CDA1 DENTT TSPX HRIHFB2216
Accession No. Q9H2G4 Q7TQI8
Description TSPY like 2(TSPYL2) Homo sapiens This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth. [provided by RefSeq, Sep 2009],
Protein Expression Amygdala,Brain,Epithelium,Fetal brain,Lung,Placenta,Testis,
Subcellular Localization nucleus,nucleoplasm,nucleolus,cytoplasm,centrosome,plasma membrane,
Protein Function function:Part of the CASK/TRB1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression.,induction:Up-regulated in growth-arrested T-cells. Induced by TGFB1 and all-trans retinoic acid in lung cancer cells (at protein level).,miscellaneous:Subject to X inactivation.,miscellaneous:Synaptic activity down-regulates TSPYL2 protein levels by inducing rapid proteasomal degradation.,PTM:Phosphorylation at Ser-20 and/or Thr-340 impairs function on cell proliferation.,similarity:Belongs to the nucleosome assembly protein (NAP) family.,subcellular location:Enriched in transcriptionally active regions of chromatin in neurons.,subunit:Interacts with histones. Interacts with CASK. Part of a complex containing CASK, TRB1 and TSPYL2.,tissue specificity:Ubiquitously expressed, with highest levels in brain, testis and heart, and lowest levels in liver and pancreas.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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