ITN1702
ITN1702
- Catalog: ITN1702
- Gene/Protein: TSPYL2 CDA1 DENTT TSPX HRIHFB2216
- Product Description: Immunotag™ TSYL2 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | TSYL2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | TSYL2 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | TSPYL2 CDA1 DENTT TSPX HRIHFB2216 |
| Accession No. | Q9H2G4 Q7TQI8 |
| Description | TSPY like 2(TSPYL2) Homo sapiens This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth. [provided by RefSeq, Sep 2009], |
| Protein Expression | Amygdala,Brain,Epithelium,Fetal brain,Lung,Placenta,Testis, |
| Subcellular Localization | nucleus,nucleoplasm,nucleolus,cytoplasm,centrosome,plasma membrane, |
| Protein Function | function:Part of the CASK/TRB1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression.,induction:Up-regulated in growth-arrested T-cells. Induced by TGFB1 and all-trans retinoic acid in lung cancer cells (at protein level).,miscellaneous:Subject to X inactivation.,miscellaneous:Synaptic activity down-regulates TSPYL2 protein levels by inducing rapid proteasomal degradation.,PTM:Phosphorylation at Ser-20 and/or Thr-340 impairs function on cell proliferation.,similarity:Belongs to the nucleosome assembly protein (NAP) family.,subcellular location:Enriched in transcriptionally active regions of chromatin in neurons.,subunit:Interacts with histones. Interacts with CASK. Part of a complex containing CASK, TRB1 and TSPYL2.,tissue specificity:Ubiquitously expressed, with highest levels in brain, testis and heart, and lowest levels in liver and pancreas., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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