ITN1733
ITN1733
- Catalog: ITN1733
- Gene/Protein: CYBA
- Product Description: Immunotag™ CY24A Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | CY24A |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein, at AA range: 80-160 |
| Specificity | CY24A Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | CYBA |
| Accession No. | P13498 Q61462 Q62737 |
| Description | cytochrome b-245 alpha chain(CYBA) Homo sapiens Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Leukocyte transendothelial migration, |
| Protein Expression | Brain, |
| Subcellular Localization | stress fiber,nucleus,mitochondrion,endosome,endoplasmic reticulum membrane,Golgi apparatus,plasma membrane,focal adhesion,membrane,integral component of membrane,apical plasma membrane,secretory granule,dendri |
| Protein Function | disease:Defects in CYBA are a cause of chronic granulomatous disease autosomal recessive cytochrome-b-negative (ARCGD) [MIM:233690]. Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.,function:Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.,miscellaneous:The heme prosthetic group could be coordinated with residues of the light chain, the heavy chain, or both, and it is possible that more than one heme is present per cytochrome b-245.,online information:CYBA mutation db,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the p22phox family.,subunit:Composed of a heavy chain (beta) and a light chain (alpha). Interacts with DUOX1, DUOX2 and TPO. Interacts with NOX3 and NOX4., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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