ITN1805
ITN1805
- Catalog: ITN1805
- Gene/Protein: MAPRE2 RP1
- Product Description: Immunotag™ MARE2 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | MARE2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | MARE2 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | MAPRE2 RP1 |
| Accession No. | Q15555 Q8R001 Q3B8Q0 |
| Description | microtubule associated protein RP/EB family member 2(MAPRE2) Homo sapiens The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. This protein is a microtubule-associated protein that is necessary for spindle symmetry during mitosis. It is thought to play a role in the tumorigenesis of colorectal cancers and the proliferative control of normal cells. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012], |
| Protein Expression | Brain,Epithelium,Lymph,Platelet, |
| Subcellular Localization | cytoplasm,microtubule cytoskeleton,microtubule plus-end, |
| Protein Function | domain:Composed of two functionally independent domains. The N-terminal domain forms an hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1.,function:May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.,similarity:Belongs to the MAPRE family.,similarity:Contains 1 CH (calponin-homology) domain.,similarity:Contains 1 EB1 C-terminal domain.,subcellular location:Associated with the microtubule network. Accumulates at the plus end of microtubules.,subunit:Interacts with DCTN1. Binds to the C-terminal domain of APC. Binds monomeric and polymerized tubulin.,tissue specificity:Expressed in different tumor cell lines. Up-regulated in activated B- and T-lymphocytes., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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