Datasheet |
|
Target Protein |
MUL1 |
Clonality |
Polyclonal |
Storage/Stability |
-20°C/1 year |
Application |
WB,ELISA |
Recommended Dilution |
WB 1:500-2000 ELISA 1:5000-20000 |
Concentration |
1 mg/ml |
Reactive Species |
Human,Mouse |
Host Species |
Rabbit |
Immunogen |
Synthesized peptide derived from part region of human protein |
Specificity |
MUL1 Polyclonal Antibody detects endogenous levels of protein. |
Purification |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form |
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
Gene Name |
MUL1 C1orf166 GIDE MAPL MULAN RNF218 |
Accession No. |
Q969V5 Q8VCM5 |
Description |
domain:The zinc finger domain is required for E3 ligase activity.,function:E3 ubiquitin-protein ligase that plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 RING-type zinc finger.,subcellular location:Transported in mitochondrion-derived vesicles from the mitochondrion to the peroxisome.,subunit:Homooligomer. Interacts with MAP3K7/TAK1.,tissue specificity:Widely expressed with highest levels in the heart, skeletal muscle, placenta, kidney and liver. Barely detectable in colon and thymus., |
Protein Expression |
Brain,Lung,Melanoma,Skin,Teratocarcinoma, |
Subcellular Localization |
nucleoplasm,cytoplasm,mitochondrion,peroxisome,membrane,integral component of membrane,axon,integral component of mitochondrial outer membrane,neuronal cell body, |
Protein Function |
domain:The zinc finger domain is required for E3 ligase activity.,function:E3 ubiquitin-protein ligase that plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 RING-type zinc finger.,subcellular location:Transported in mitochondrion-derived vesicles from the mitochondrion to the peroxisome.,subunit:Homooligomer. Interacts with MAP3K7/TAK1.,tissue specificity:Widely expressed with highest levels in the heart, skeletal muscle, placenta, kidney and liver. Barely detectable in colon and thymus., |
Usage |
For Research Use Only! Not for diagnostic or therapeutic procedures. |