ITN1969
ITN1969
- Catalog: ITN1969
- Gene/Protein: BCHE CHE1
- Product Description: Immunotag™ CHLE Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | CHLE |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | CHLE Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | BCHE CHE1 |
| Accession No. | P06276 Q03311 |
| Description | butyrylcholinesterase(BCHE) Homo sapiens This gene encodes a cholinesterase enzyme and member of the type-B carboxylesterase/lipase family of proteins. The encoded enzyme exhibits broad substrate specificity and is involved in the detoxification of poisons including organophosphate nerve agents and pesticides, and the metabolism of drugs including cocaine, heroin and aspirin. Humans homozygous for certain mutations in this gene exhibit prolonged apnea after administration of the muscle relaxant succinylcholine. [provided by RefSeq, Jul 2016], |
| Protein Expression | Brain,Fetus,Liver,Plasma,Skin,Stomach, |
| Subcellular Localization | extracellular region,nuclear envelope lumen,endoplasmic reticulum lumen,membrane,integral component of membrane,blood microparticle, |
| Protein Function | catalytic activity:An acylcholine + H(2)O = choline + a carboxylate.,disease:Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:177400]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.,miscellaneous:Cholinesterase is highly reactive with organophosphate esters.,similarity:Belongs to the type-B carboxylesterase/lipase family.,subunit:Homotetramer. The tetramer is composed of two dimers. The two subunits in a dimer are linked by a disulfide bond.,tissue specificity:Present in most cells except erythrocytes., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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