ITN1986
ITN1986
- Catalog: ITN1986
- Gene/Protein: GPX3 GPXP
- Product Description: Immunotag™ GPX3 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | GPX3 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Rat,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | GPX3 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | GPX3 GPXP |
| Accession No. | P22352 P46412 P23764 |
| Description | glutathione peroxidase 3(GPX3) Homo sapiens The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is secreted, and is abundantly found in plasma. Downregulation of expression of this gene by promoter hypermethylation has been observed in a wide spectrum of human malignancies, including thyroid cancer, hepatocellular carcinoma and chronic myeloid leukemia. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designa |
| Cell Pathway/ Category | Glutathione metabolism,Arachidonic acid metabolism, |
| Protein Expression | Brain,Duodenum,Fetal liver,Kidney,Lung,Lymphocyte,Pancreas,Placenta, |
| Subcellular Localization | extracellular region,extracellular space,extracellular exosome, |
| Protein Function | catalytic activity:2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.,function:Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.,online information:Glutathione peroxidase entry,PTM:The N-terminus is blocked.,similarity:Belongs to the glutathione peroxidase family.,subunit:Homotetramer.,tissue specificity:Secreted in plasma., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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