ITN2054
ITN2054
- Catalog: ITN2054
- Gene/Protein: PAPPA2 PLAC3
- Product Description: Immunotag™ PAPP2 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | PAPP2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | PAPP2 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | PAPPA2 PLAC3 |
| Accession No. | Q9BXP8 |
| Description | pappalysin 2(PAPPA2) Homo sapiens This gene encodes a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010], |
| Protein Expression | Brain,Placenta,Pooled,Term placenta, |
| Subcellular Localization | extracellular region,intracellular,extracellular exosome, |
| Protein Function | catalytic activity:Cleavage of the 143-Ser-|-Lys-144 bond in insulin-like growth factor binding protein (IGFBP)-5.,cofactor:Binds 1 zinc ion per subunit.,function:Metalloproteinase which specifically cleaves IGFBP-5. Shows limited proteolysis toward IGFBP-3.,similarity:Belongs to the peptidase M43B family.,similarity:Contains 5 Sushi (CCP/SCR) domains.,subunit:Monomer.,tissue specificity:Expressed abundantly in placenta, and non-pregnant mammary gland with low expression in the kidney, fetal brain and pancreas., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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