ITN2113
ITN2113
- Catalog: ITN2113
- Gene/Protein: BGLAP
- Product Description: Immunotag™ OSTCN Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | OSTCN |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Rat,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | OSTCN Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | BGLAP |
| Accession No. | P02818 P86546 P04640 |
| Description | bone gamma-carboxyglutamate protein(BGLAP) Homo sapiens This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015], |
| Protein Expression | Brain,Cerebellum,Colon,Lung carcinoma,Skin,Testis,Uterus, |
| Subcellular Localization | extracellular space,cytoplasm,endoplasmic reticulum lumen,rough endoplasmic reticulum,Golgi lumen,dendrite,membrane-bounded vesicle,perikaryon, |
| Protein Function | function:Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.,function:Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. May act as a cotranscription partner of NFE2L2 involved in regulation of polyamine-induced transcription of SSAT.,induction:By polyamine analogs in analog-sensitive H157 cells.,online information:Osteocalcin entry,PTM:Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.,similarity:Belongs to the osteocalcin/matrix Gla protein family.,similarity:Contains 1 Gla (gamma-carboxy-glutamate) domain.,subcellular location:Associated with the kinetochore.,subunit:Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Interacts with COPS7A. Interacts via its coiled-coil domain with the leucine-zipper domain of NFE2L2. The interaction with NFE2L2 is required for the transcriptional regulation of SSAT.,tissue specificity:Highest levels of expression in heart and skeletal muscle, with significant levels expressed in kidney and liver., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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